Electron optic study of the lesions induced by Creutzfeldt--Jakob disease virus in the guinea pig.

An electron microscopic study was performed in brain sections from guinea pigs with experimental Creutzfeldt-Jakob disease. Vacuolation of the neuropil, dilatations of the endoplasmic reticulum and lipid accumulations were observed in the grey matter, while the white matter exhibited intramyelinic vacuoles.