Optimizations of Cas12a- and Cas12i-based adenine base editors for efficient precision editing in the plant genome.
Journal of integrative plant biology, 68(9): 3169-3171 PMID 41664360 DOI 10.1111/jipb.70177
Abstract
A strategy coupling high-activity nucleases with dimeric TadA-8e optimizes plant Cas12-based adenine base editors, boosts editing efficiency, and provides precise editors for crop breeding and genomics research.