Reverse engineering the beat: Assembloid modeling of sympathetic control of the heart.
Cell stem cell, 33(1): 1-3 PMID 41512830 DOI 10.1016/j.stem.2025.12.012
Abstract
Liu et al.1 generate human sympathetic ganglion organoids and assemble them with heart-forming organoids to build functionally connected sympathetic-cardiac organoids in vitro. Their platform captures autonomic development, neuromodulation of heart function, and metabolic injury, opening new opportunities to study human autonomic disorders and cardiometabolic disease.2.