Unlocking the epigenome: Single-cell histone profiling in cortical development.

Ditzer et al. used single-cell cytometry by time-of-flight-based method for epigenetic analysis to profile histone modifications in the primary human cortex and cortical organoids, revealing how chromatin states, particularly H3K27me3, govern neural progenitor fate. This study highlights the potential of multiplexed epigenomics in understanding human brain development.