Association of Gut-Microbiome and mental health and effects of probiotics on psychiatric disorders: A Meta-analysis and systematic review.
Nigerian medical journal : journal of the Nigeria Medical Association, 66(1): 13-25 PMID 40309529 DOI 10.71480/nmj.v66i1.601
Abstract
BACKGROUNDA correlation between gut microbiome and mental health has drawn significant attention lately. The effects of microbiome microorganisms and their byproducts on disease states represent a complex and dynamic field of study. The objective of this article is to review the association of gut microbes and mental health and the effects of probiotics on psychiatric disorders, if any.
METHODOLOGYThis meta-analysis was conducted using the PRISMA standards. We have compiled the most recent advancements in the field according to human research published in this Systematic review and meta-analysis.
RESULTSThe forest plot analysis revealed that probiotics or probiotics combined with other intervention modalities did significantly reduce some extent of mental disorders in comparison to the control group (Standardized mean difference) SMD = 0.95, 95% Confidence Interval (CI): -6.52 to 8.42, P value< 0.01.
CONCLUSIONOverall, the reviewed literature supports the importance of gut microbiota-brain interaction in human mental illnesses, including the impact of probiotics on mental health outcomes and brain connection.