Orthogonal genome editing and transcriptional activation in tomato using CRISPR-Combo systems.
Plant cell reports, 43(9): 227 PMID 39235647 DOI 10.1007/s00299-024-03316-6
Аннотация
The CRISPR-Combo systems (Cas9-Combo and CBE-Combo) are designed for comprehensive genetic manipulation, enabling Cas9-based targeted mutagenesis or cytosine base editing with simultaneous gene activation in tomato stable lines.