When size matters: A novel compact Cas12a variant for in vivo genome editing.
PLoS biology, 22(7): e3002637 PMID 39018342 DOI 10.1371/journal.pbio.3002637
Abstract
A new study characterizes and improves a novel small Cas12a variant before adapting it for in vivo genome editing by delivery via adeno-associated virus (AAV) vectors, showcasing the potential of small CRISPR systems and their compatibility with viral vectors.