Improving cellular diversity in human cerebellar organoids.
Cell stem cell, 31(1): 3-4 PMID 38181748 DOI 10.1016/j.stem.2023.12.007
Abstract
The developing human cerebellum has a greater diversity of progenitor types than that of the mouse, necessitating a human-based model for studying cerebellar development and disease. Atamian et al.1 developed a 3D organoid model of cerebellar development, which recapitulates many cell types found in the developing human cerebellum, including Purkinje-neuron-like cells.