The case of the missing Ks: Base editor screen to assess cellular fitness at single lysines.
Molecular cell, 83(24): 4442-4444 PMID 38134884 DOI 10.1016/j.molcel.2023.11.037
Аннотация
In this issue of Molecular Cell, Bao et al.1 set out to elucidate "functional lysines" in the genome using adenine base editors. The study reveals several cases of alteration of functions that previous canonical CRISPR-Cas9 screens were unable to detect.