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Mol Cancer · 2022

Optimization of Cas9 RNA sequence to reduce its unexpected effects as a microRNA sponge.

Jiang J, Zeng T, Zhang L, Fan X, Jin Q, Ni H, Ye Y, Cheng L, Li L, Wang L, Xu S, Yang Y, Gu J, Guo B, Wang L, Li X, Qin Y, Li J, Wang J, Chen X, Wu M, Ying QL, Qin X, Wang Y, Wang Y

Molecular cancer, 21(1): 136 PMID 35751058 DOI 10.1186/s12943-022-01604-x

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Аннотация

UNLABELLEDCas9 RNA functions as a miRNA sponge. Let-7 is the dominant regulated miRNA by Cas9 RNA. RNA sequence optimization of Cas9 by synonymous mutation improves its safety.

SUPPLEMENTARY INFORMATIONThe online version contains supplementary material available at 10.1186/s12943-022-01604-x.

Цитирование