Founder cells shape brain evolution.
Cell, 184(8): 1965-1967 PMID 33861961 DOI 10.1016/j.cell.2021.03.045
Abstract
Humans have an extraordinarily expanded and complex cerebral cortex, relative to non-human primates. Yet the mechanisms underlying cortical differences across evolution are unclear. A new study by Benito-Kwiecinski et al. employs cerebral organoids derived across great apes to implicate neuroepithelial progenitor shape transitions in human cortical expansion.