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Chem Commun (Camb) · 2020

ZIF-C for targeted RNA interference and CRISPR/Cas9 based gene editing in prostate cancer.

Poddar A, Pyreddy S, Carraro F, Dhakal S, Rassell A, Field MR, Reddy TS, Falcaro P, Doherty CM, Shukla R

Chemical communications (Cambridge, England), 56(98): 15406-15409 PMID 33196071 DOI 10.1039/d0cc06241c

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Abstract

Gene therapy is highly suited for prostate cancer (PC). Metal-organic-frameworks (MOFs) are potential gene delivery systems. Target-specific cytoplasmic and nuclear knockdown in host gene expression using ZIF-C is shown for the first time through RNAi and CRISPR/Cas9 based gene editing in PC cells. A green tea phytochemical coating enhances intracellular delivery.

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