Your Base Editor Might Be Flirting with Single (Stranded) DNA: Faithful On-Target CRISPR Base Editing without Promiscuous Deamination.
Molecular cell, 79(5): 703-704 PMID 32888434 DOI 10.1016/j.molcel.2020.07.030
Abstract
Jin et al. (2020) engineered new variants of CRISPR base editors that make precise genomic edits in rice protoplasts while minimizing untargeted mutagenesis.