Choroid Plexus Organoids: Harnessing CSF Gatekeepers for Brain Therapeutics.
Cell stem cell, 27(2): 191-192 PMID 32763178 DOI 10.1016/j.stem.2020.07.009
Abstract
Barrier properties of the choroid plexus (ChP) help protect the brain from the external world. In Science, Pellegrini et al. (2020) report the successful creation of human ChP organoids, which produce a cerebrospinal fluid-like secretion and recapitulate barrier functions, thereby inspiring new advances for targeted brain therapeutics.