Gene Editing Expands the Donor Pool for CCR5-Negative Stem Cell Transplants.
Cell stem cell, 25(6): 735-736 PMID 31809736 DOI 10.1016/j.stem.2019.11.006
Abstract
Cell therapy efforts for treating HIV+ patients are challenged by limited availability of donors with naturally occurring CCR5 mutations conferring resistance. Xu et al. (2019) report a CRISPR-based method for disrupting CCR5 in hematopoietic stem cells prior to transplant, providing a proof of concept for expanding the pool of potential donors.