CRISPR screens are feasible in TP53 wild-type cells.
Molecular systems biology, 15(8): e8679 PMID 31464370 DOI 10.15252/msb.20188679
Abstract
A recent study by Haapaniemi et al (2018) reported that intact p53 signaling hampers CRISPR-based functional genomic screens. Brown et al report good performance of genome-scale screens in TP53 wild-type cells and reiterate best practices for CRISPR screening.