Breakthrough Moments: Genome Editing and Organoids.
Cell stem cell, 24(6): 841-842 PMID 31173713 DOI 10.1016/j.stem.2019.05.008
Аннотация
Six years ago, Schwank et al. (2013) adapted CRISPR-Cas9 and organoid technology to repair genetic diseases in patient-derived tissues. We shine a spotlight on how this work has inspired the development of tools to study and correct genetic diseases in experimental systems, with the ultimate goal of treating human disease.