Of Mice and Men: Species-Specific Organoid Models of Neocortical Malformation.
Cell stem cell, 20(4): 421-422 PMID 28388422 DOI 10.1016/j.stem.2017.03.005
Аннотация
Cellular changes underlying malformations of human cortical development may be difficult to identify with traditional mouse models. Two recent Cell Stem Cell papers, Li et al. (2017) and Bershteyn et al. (2017), use human cerebral organoids to identify specific cellular defects in neurogenesis that may explain PTEN-related macrocephaly and Miller-Dieker lissencephaly.