Somatic Genome Editing Goes Viral.
Trends in molecular medicine, 22(10): 831-833 PMID 27555346 DOI 10.1016/j.molmed.2016.08.004
Abstract
Generating new mouse models of cancer is a challenging and laborious task that can require years of investment to interrogate a single gene. Now, Jonkers and colleagues describe the first application of CRISPR-based genome editing in the mammary gland, providing a new approach to dissect complex genetic interactions in vivo.